Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical and metabolic phenotypes of Oxford Biobank subjects with variations in human flavin-containing monooxygenase 5 (FMO5).

Metabolomics : Official journal of the Metabolomic Society - 9 Sept 2025

Everett Jeremy R, Karpe Fredrik, Le Guennec Adrien, Neville Matt, Redfield Christina

Abstract excerpt

INTRODUCTION: Knockout of the Fmo5 gene in mice led to a lean, slow-ageing phenotype characterised by the presence of 2,3-butanediol isomers in their urine and plasma. Oral treatment of wildtype mice with 2,3-butanediol led to a low cholesterol, low epididymal fat phenotype. OBJECTIVES: Determine if significant, heterozygous coding variations in human FMO5 would give rise to similar clinical and metabolic...

Read the complete abstract on PubMed

Topics

Humans
Female
Phenotype
Oxygenases
Butylene Glycols
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adult

Biological Specimen Banks

Animals

Mice

Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 40924250
DOI: 10.1007/s11306-025-02308-1
PMCID: PMC12420700

Genes

FMO5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical and metabolic phenotypes of Oxford Biobank subjects with variations in human flavin-containing monooxygenase 5 (FMO5).PMID 40924250Read ↗

The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing.Semantic proximity Read ↗

Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut Bacteria.Semantic proximity Read ↗

Characterising a healthy adult with a rare HAO1 knockout to support a therapeutic strategy for primary hyperoxaluriaSemantic proximity Read ↗

The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance.Semantic proximity Read ↗

Loss-of-function variants influence the human serum metabolome.Semantic proximity Read ↗

Flavin-containing monooxygenases: mutations, disease and drug response.Semantic proximity Read ↗

Systems biology and machine learning approaches identify metabolites that influence dietary lifespan and healthspan responses across flies and humansSemantic proximity Read ↗

Where to go with FTO?Semantic proximity Read ↗

Prevalence of loss-of-function FTO mutations in lean and obese individuals.Semantic proximity Read ↗

Deep phenotyping of a healthy human HAO1 knockout informs therapeutic development for primary hyperoxaluria type 1Semantic proximity Read ↗

Drug metabolism by flavin-containing monooxygenases of human and mouse.Semantic proximity Read ↗

Genetic variability at the human FMO1 locus: significance of a basal promoter yin yang 1 element polymorphism (FMO1*6).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.