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Article

The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing.

Biochemical pharmacology - 1 Aug 2015

Gonzalez Malagon Sandra G, Melidoni Anna N, Hernandez Diana, Omar Bilal A, Houseman Lyndsey, Veeravalli Sunil, Scott Flora, Varshavi Dorsa, Everett Jeremy, Tsuchiya Yugo, Timms John F, Phillips Ian R, Shephard Elizabeth A

Abstract excerpt

We report the production and metabolic phenotype of a mouse line in which the Fmo5 gene is disrupted. In comparison with wild-type (WT) mice, Fmo5(-/-) mice exhibit a lean phenotype, which is age-related, becoming apparent after 20 weeks of age. Despite greater food intake, Fmo5(-/-) mice weigh less, store less fat in white adipose tissue (WAT), have lower plasma glucose and cholesterol concentrations and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26049045
DOI: 10.1016/j.bcp.2015.05.013
PMCID: PMC4509511

Genes

GPD1
FMO5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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