Article
The sequential phosphorylation of PHF10 subunit of the PBAF chromatin-remodeling complex determines different properties of the PHF10 isoforms.
Biology open - 15 Jan 2020
Sheynov Andrey A, Tatarskiy Victor V, Tatarskiy Eugene V, Nabirochkina Elena N, Georgieva Sofia G, Soshnikova Nataliya V
Abstract excerpt
The mammalian PBAF subfamily of SWI/SNF chromatin remodeling complexes plays a wide role in the regulation of gene expression. PHF10 is a subunit of the signature module of PBAF, responsible for its interaction with chromatin. PHF10 is represented by four different isoforms, which are alternatively incorporated in the complex. Two of PHF10 isoforms lacking C-terminal PHD domains contain a cluster of...
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