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Article

Sustained N-methyl-d-aspartate receptor hypofunction remodels the dopamine system and impairs phasic signaling.

The European journal of neuroscience - 1 Jul 2014

Ferris Mark J, Milenkovic Marija, Liu Shuai, Mielnik Catharine A, Beerepoot Pieter, John Carrie E, España Rodrigo A, Sotnikova Tatyana D, Gainetdinov Raul R, Borgland Stephanie L, Jones Sara R, Ramsey Amy J

Abstract excerpt

Chronic N-methyl-d-aspartate receptor (NMDAR) hypofunction has been proposed as a contributing factor to symptoms of schizophrenia. However, it is unclear how sustained NMDAR hypofunction throughout development affects other neurotransmitter systems that have been implicated in the disease. Dopamine neuron biochemistry and activity were examined to determine whether sustained NMDAR hypofunction causes a state of...

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Identifiers

PMID: 24754704
DOI: 10.1111/ejn.12594
PMCID: PMC4331169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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