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Article

Decreased dopamine D4 receptor expression increases extracellular glutamate and alters its regulation in mouse striatum.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2009

Thomas Theresa Currier, Grandy David K, Gerhardt Greg A, Glaser Paul E A

Abstract excerpt

To better understand the effect of the dopamine D4 receptor (DRD4) on glutamate (Glu) neurotransmission in the brain, we utilized transgenic mice with partial or complete removal of functional DRD4 plasma membrane expression (DRD4+/- and DRD4-/-, respectively). We measured resting extracellular Glu levels, Glu clearance kinetics, and KCl-evoked release of Glu in the striatum and nucleus accumbens core of these...

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Identifiers

PMID: 18536704
DOI: 10.1038/npp.2008.74
PMCID: PMC7223095

Genes

DRD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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