Article
Schizophrenia-like phenotypes in mice with NMDA receptor ablation in intralaminar thalamic nucleus cells and gene therapy-based reversal in adults.
Translational psychiatry - 28 Feb 2017
Yasuda K, Hayashi Y, Yoshida T, Kashiwagi M, Nakagawa N, Michikawa T, Tanaka M, Ando R, Huang A, Hosoya T, McHugh T J, Kuwahara M, Itohara S
Abstract excerpt
In understanding the mechanism of schizophrenia pathogenesis, a significant finding is that drug abuse of phencyclidine or its analog ketamine causes symptoms similar to schizophrenia. Such drug effects are triggered even by administration at post-adolescent stages. Both drugs are N-methyl-d-aspartate receptor (NMDAR) antagonists, leading to a major hypothesis that glutamate hypofunction underlies schizophrenia...
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