Article

Functions of GluN2D-containing NMDA receptors in dopamine neurons of the substantia nigra pars compacta

2018-01-01

Abstract excerpt

Dopamine (DA) neurons of the substantia nigra pars compacta (SNc) have a key role in regulation of voluntary movement control. Their death is a hallmark of Parkinson’s disease, characterised by inhibited motor control, including muscle rigidity and tremor. Excitatory input to SNc-DA neurons is primarily from the subthalamic nucleus, and in PD these afferents display a higher frequency firing, as well as increased...

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Literature Corpus work: d4265e21-1932-5de5-8caf-8cc91b073eb9
DOI: 10.17863/cam.18860

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