Article

Schizophrenia-associated 22q11.2 deletion elevates striatal acetylcholine and disrupts thalamostriatal projections to produce amotivation in mice

2025-06-21

Abstract excerpt

<h4>Summary</h4> Schizophrenia is a complex neurodevelopmental disorder characterized by cognitive dysfunction, hallucinations, and negative symptoms such as amotivation. Negative symptoms are largely resistant to current antipsychotic treatments, and the neural circuits underlying amotivational states remain poorly defined. Here, using a mouse model of schizophrenia-associated 22q11.2 deletion syndrome (22q11DS)...

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Literature Corpus work: cc5f8484-e43f-5575-ab09-9fa1948d541d
DOI: 10.1101/2025.06.20.660782

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