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Article

Increased dopamine D2 receptor activity in the striatum alters the firing pattern of dopamine neurons in the ventral tegmental area.

Proceedings of the National Academy of Sciences of the United States of America - 24 Mar 2015

Krabbe Sabine, Duda Johanna, Schiemann Julia, Poetschke Christina, Schneider Gaby, Kandel Eric R, Liss Birgit, Roeper Jochen, Simpson Eleanor H

Abstract excerpt

There is strong evidence that the core deficits of schizophrenia result from dysfunction of the dopamine (DA) system, but details of this dysfunction remain unclear. We previously reported a model of transgenic mice that selectively and reversibly overexpress DA D2 receptors (D2Rs) in the striatum (D2R-OE mice). D2R-OE mice display deficits in cognition and motivation that are strikingly similar to the deficits...

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Identifiers

PMID: 25675529
DOI: 10.1073/pnas.1500450112
PMCID: PMC4378386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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