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Article

Neuregulin-1 regulates LTP at CA1 hippocampal synapses through activation of dopamine D4 receptors.

Proceedings of the National Academy of Sciences of the United States of America - 7 Oct 2008

Kwon Oh Bin, Paredes Daniel, Gonzalez Carmen M, Neddens Jörg, Hernandez Luis, Vullhorst Detlef, Buonanno Andres

Abstract excerpt

Neuregulin-1 (NRG-1) is genetically linked with schizophrenia, a neurodevelopmental cognitive disorder characterized by imbalances in glutamatergic and dopaminergic function. NRG-1 regulates numerous neurodevelopmental processes and, in the adult, suppresses or reverses long-term potentiation (LTP) at hippocampal glutamatergic synapses. Here we show that NRG-1 stimulates dopamine release in the hippocampus and...

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Identifiers

PMID: 18832154
DOI: 10.1073/pnas.0805722105
PMCID: PMC2563131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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