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Article

Lentiviral-induced high-grade gliomas in rats: the effects of PDGFB, HRAS-G12V, AKT, and IDH1-R132H.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics - 1 Jul 2014

Lynes John, Wibowo Mia, Koschmann Carl, Baker Gregory J, Saxena Vandana, Muhammad A K M G, Bondale Niyati, Klein Julia, Assi Hikmat, Lieberman Andrew P, Castro Maria G, Lowenstein Pedro R

Abstract excerpt

In human gliomas, the RTK/RAS/PI(3)K signaling pathway is nearly always altered. We present a model of experimental gliomagenesis that elucidates the contributions of genes involved in this pathway (PDGF-B ligand, HRAS-G12V, and AKT). We also examine the effect on gliomagenesis by the potential modifier gene, IDH1-R132H. Injections of lentiviral-encoded oncogenes induce de novo gliomas of varying penetrance,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

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Source

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Identifiers

PMID: 24752661
DOI: 10.1007/s13311-014-0269-y
PMCID: PMC4121445

Genes

IDH1
HRAS
PDGFB

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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