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Article

Lentiviral-Induced Spinal Cord Gliomas in Rat Model.

International journal of molecular sciences - 30 Nov 2021

Nagarajan Purva P, Tora Muhibullah S, Neill Stewart G, Federici Thais, Texakalidis Pavlos, Donsante Anthony, Canoll Peter, Lei Kecheng, Boulis Nicholas M

Abstract excerpt

Intramedullary spinal cord tumors are a rare and understudied cancer with poor treatment options and prognosis. Our prior study used a combination of PDGF-B, HRAS, and p53 knockdown to induce the development of high-grade glioma in the spinal cords of minipigs. In this study, we evaluate the ability of each vector alone and combinations of vectors to produce high-grade spinal cord gliomas. Eight groups of rats (n...

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Source

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Identifiers

PMID: 34884748
DOI: 10.3390/ijms222312943
PMCID: PMC8657985

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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