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H3.3 G34R-engineered murine glioma reproduces diffuse perineuronal infiltration of diffuse hemispheric glioma, H3 G34-mutant.

Biochemical and biophysical research communications - 16 Apr 2026

Okubo Takafumi, Miyai Masafumi, Tomita Hiroyuki, Mori Kosuke, Niwa Ayumi, Imaizumi Yuko, Ichihashi Koki, Taniguchi Toshiaki, Muto Aoi, Suzuki Hiroki, Kanayama Tomohiro, Sugie Shigeyuki, Izumo Tsuyoshi, Hara Akira

Abstract excerpt

BACKGROUND: Diffuse hemispheric glioma, H3 G34-mutant (DHG-H3G34), is an aggressive pediatric brain tumor characterized by a distinctive neurotropic invasion pattern, including prominent perineuronal satellitosis (PS). The molecular mechanisms underlying this phenotype remain unclear owing to the scarcity of faithful preclinical models. METHODS: A murine glioma model was generated by introducing the H3.3 G34R...

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PMID: 41719882
DOI: 10.1016/j.bbrc.2026.153471

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