Article
Genetic driver mutations define the expression signature and microenvironmental composition of high-grade gliomas.
Glia - 1 Dec 2017
Herting C J, Chen Z, Pitter K L, Szulzewsky F, Kaffes I, Kaluzova M, Park J C, Cimino P J, Brennan C, Wang B, Hambardzumyan D
Abstract excerpt
High-grade gliomas (HGG), including glioblastomas, are characterized by invasive growth, resistance to therapy, and high inter- and intra-tumoral heterogeneity. The key histological hallmarks of glioblastoma are pseudopalisading necrosis and microvascular proliferation, which allow pathologists to distinguish glioblastoma from lower-grade gliomas. In addition to being genetically and molecularly heterogeneous,...
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