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Article

The genetic basis of obesity-associated type 2 diabetes (diabesity) in polygenic mouse models

21 Apr 2014

Abstract excerpt

Obesity-associated diabetes ("diabesity") in mouse strains is characterized by severe insulin resistance, hyperglycaemia and progressive failure, and loss of beta cells. This condition is observed in inbred obese mouse strains such as the New Zealand Obese (NZO/HlLt and NZO/HlBomDife) or the TALLYHO/JngJ mouse. In lean strains such as C57BLKS/J, BTBR T+tf/J or DBA/2 J carrying diabetes susceptibility genes...

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PMID: 24752583
DOI: 10.1007/s00335-014-9514-2

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