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Article

Pathophysiology and genetics of obesity and diabetes in the New Zealand obese mouse: a model of the human metabolic syndrome.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Kluge Reinhart, Scherneck Stephan, Schürmann Annette, Joost Hans-Georg

Abstract excerpt

The New Zealand Obese (NZO) mouse is one of the most thoroughly investigated polygenic models for the human metabolic syndrome and type 2 diabetes. It presents the main characteristics of the disease complex, including early-onset obesity, insulin resistance, dyslipidemia, and hypertension. As a consequence of this syndrome, a combination of lipotoxicity and glucotoxicity produces beta-cell failure and apoptosis...

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Identifiers

PMID: 22893401
DOI: 10.1007/978-1-62703-068-7_5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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