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Differential Levels of Diabetogenic Stress in Two New Mouse Models of Obesity and Type 2 Diabetes

1 Feb 2004

Abstract excerpt

The genetic basis for the more common forms of human obesity predisposing to insulin resistance and development of type 2 diabetes is multigenic rather than monogenic in origin. New mouse "diabesity" models have been created by combining independent diabetes risk-conferring quantitative trait loci from two unrelated parental strains: New Zealand Obese (NZO/HlLt) and Nonobese Nondiabetic (NON/Lt). F1 hybrid males,...

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PMID: 14749259
DOI: 10.2337/diabetes.53.2007.s4

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