Article
Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in mice.
PLoS genetics - 25 Jul 2008
Dokmanovic-Chouinard Marija, Chung Wendy K, Chevre Jean-Claude, Watson Elizabeth, Yonan Jason, Wiegand Beebe, Bromberg Yana, Wakae Nao, Wright Chris V, Overton John, Ghosh Sujoy, Sathe Ganesh M, Ammala Carina E, Brown Kathleen K, Ito Rokuro, LeDuc Charles, Solomon Keely, Fischer Stuart G, Leibel Rudolph L
Abstract excerpt
In 404 Lep(ob/ob) F2 progeny of a C57BL/6J (B6) x DBA/2J (DBA) intercross, we mapped a DBA-related quantitative trait locus (QTL) to distal Chr1 at 169.6 Mb, centered about D1Mit110, for diabetes-related phenotypes that included blood glucose, HbA1c, and pancreatic islet histology. The interval was refined to 1.8 Mb in a series of B6.DBA congenic/subcongenic lines also segregating for Lep(ob). The phenotypes of...
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