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Article

NIDDM genes in mice: deleterious synergism by both parental genomes contributes to diabetogenic thresholds.

Diabetes - 1 Aug 1998

Leiter E H, Reifsnyder P C, Flurkey K, Partke H J, Junger E, Herberg L

Abstract excerpt

We used mouse genetics to model how polygenic thresholds for the transition from impaired glucose tolerance (IGT) to NIDDM are reached. NON/Lt and NZO/Hl are inbred mouse strains selected for IGT and polygenic obesity, respectively. Their F1 male progeny consistently developed NIDDM. Genetic analysis of F2 males from both cross directions identified an NON-derived diabetogenic locus, Nidd 1, on chromosome (Chr) 4...

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Source

Identifiers

PMID: 9703330
DOI: 10.2337/diab.47.8.1287

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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