Article
Systems genetics of susceptibility to obesity-induced diabetes in mice.
Physiological genomics - 18 Jan 2012
Davis Richard C, van Nas Atila, Castellani Lawrence W, Zhao Yi, Zhou Zhiqiang, Wen Pingzi, Yu Suzanne, Qi Hongxiu, Rosales Melenie, Schadt Eric E, Broman Karl W, Péterfy Miklós, Lusis Aldons J
Abstract excerpt
Inbred strains of mice are strikingly different in susceptibility to obesity-driven diabetes. For instance, deficiency in leptin receptor (db/db) leads to hyperphagia and obesity in both C57BL/6 and DBA/2 mice, but only on the DBA/2 background do the mice develop beta-cell loss leading to severe diabetes, while C57BL/6 mice are relatively resistant. To further investigate the genetic factors predisposing to...
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