Article
Deconstructing and reconstructing obesity-induced diabetes (diabesity) in mice.
Diabetes - 1 Mar 2002
Reifsnyder Peter C, Leiter Edward H
Abstract excerpt
Obesity-driven type 2 diabetes (diabesity) involves complex genetic and environmental interactions to trigger disease. Here, we combine variable numbers of known quantitative trait loci (QTL) for obesity and diabetes contributed by New Zealand Obese (NZO/HlLt) and Nonobese Nondiabetic (NON/Lt) strains in the form of 10 interval-directed recombinant congenic strains (RCS), with NON/Lt as the background strain, to...
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