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Article

Resistance to cyclosporin A derives from mutations in hepatitis C virus nonstructural proteins.

Biochemical and biophysical research communications - 23 May 2014

Arai Masaaki, Tsukiyama-Kohara Kyoko, Takagi Asako, Tobita Yoshimi, Inoue Kazuaki, Kohara Michinori

Abstract excerpt

Cyclosporine A (CsA) is an immunosuppressive drug that targets cyclophilins, cellular cofactors that regulate the immune system. Replication of hepatitis C virus (HCV) is suppressed by CsA, but the molecular basis of this suppression is still not fully understood. To investigate this suppression, we cultured HCV replicon cells (Con1, HCV genotype 1b, FLR-N cell) in the presence of CsA and obtained nine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24751518
DOI: 10.1016/j.bbrc.2014.04.053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Resistance to cyclosporin A derives from mutations in hepatitis C virus nonstructural proteins.PMID 24751518Read ↗

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