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Article

Identification of cellular and viral factors related to anti‐hepatitis C virus activity of cyclophilin inhibitor

26 Jun 2009

Abstract excerpt

We have so far reported that an immunosuppressant cyclosporin A (CsA), a well-known cyclophilin (CyP) inhibitor (CPI), strongly suppressed hepatitis C virus (HCV) replication in cell culture, and that CyPB was a cellular cofactor for viral replication. To further investigate antiviral mechanisms of CPI, we here developed cells carrying CsA-resistant HCV replicons, by culturing the HCV subgenomic replicon cells...

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PMID: 19659609
DOI: 10.1111/j.1349-7006.2009.01263.x

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