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Article

Sensitivity of hepatitis C virus to cyclosporine A depends on nonstructural proteins NS5A and NS5B.

Hepatology (Baltimore, Md.) - 1 Oct 2007

Fernandes Fiona, Poole Daniel S, Hoover Spencer, Middleton Rannveig, Andrei Adin-Cristian, Gerstner Justin, Striker Rob

Abstract excerpt

UNLABELLED: HCV re-occurs after liver transplantation and increases mortality. Cyclosporine, but not tacrolimus, has potent antiviral effects against HCV replication in cell culture. To determine the conditions, if any, under which HCV is susceptible to cyclosporine in vivo, we selected for cyclo...

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Share to Antiviral Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17600342
DOI: 10.1002/hep.21809

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17600342-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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Sensitivity of hepatitis C virus to cyclosporine A depends on nonstructural proteins NS5A and NS5B.PMID 17600342Read ↗

Cyclosporine inhibits a direct interaction between cyclophilins and hepatitis C NS5A.Semantic proximity Read ↗

Mutations in the hepatitis C virus polymerase that increase RNA binding can confer resistance to cyclosporine A.Semantic proximity Read ↗

A major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approach.Semantic proximity Read ↗

Resistance to cyclosporin A derives from mutations in hepatitis C virus nonstructural proteins.Semantic proximity Read ↗

Cyclophilin A Is an Essential Cofactor for Hepatitis C Virus Infection and the Principal Mediator of Cyclosporine Resistance In VitroSemantic proximity Read ↗

HCV genotype 1b chimeric replicon with NS5B of JFH-1 exhibited resistance to cyclosporine A.Semantic proximity Read ↗

Characterization of Hepatitis C Virus Subgenomic Replicon Resistance to Cyclosporine In VitroSemantic proximity Read ↗

Mutational analysis reveals a novel role for hepatitis C virus NS5A domain I in cyclophilin-dependent genome replication.Semantic proximity Read ↗

Chemical genetics approach to hepatitis C virus replication: cyclophilin as a target for anti‐hepatitis C virus strategySemantic proximity Read ↗

Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics.Semantic proximity Read ↗

Inhibition of HCV replication by cyclophilin antagonists is linked to replication fitness and occurs by inhibition of membranous web formation.Semantic proximity Read ↗

The Cyclophilin Inhibitor SCY-635 Disrupts Hepatitis C Virus NS5A-Cyclophilin A ComplexesSemantic proximity Read ↗

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