Article
Diverse effects of cyclosporine on hepatitis C virus strain replication.
Journal of virology - 1 May 2006
Ishii Naoto, Watashi Koichi, Hishiki Takayuki, Goto Kaku, Inoue Daisuke, Hijikata Makoto, Wakita Takaji, Kato Nobuyuki, Shimotohno Kunitada
Abstract excerpt
Recently, a production system for infectious particles of hepatitis C virus (HCV) utilizing the genotype 2a JFH1 strain has been developed. This strain has a high capacity for replication in the cells. Cyclosporine (CsA) has a suppressive effect on HCV replication. In this report, we characterize the anti-HCV effect of CsA. We observe that the presence of viral structural proteins does not influence the anti-HCV...
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