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Article

HCV genotype 1b chimeric replicon with NS5B of JFH-1 exhibited resistance to cyclosporine A.

Archives of virology - 1 Jan 2009

Abe Ken-ichi, Ikeda Masanori, Ariumi Yasuo, Dansako Hiromichi, Wakita Takaji, Kato Nobuyuki

Abstract excerpt

Cyclosporine A (CsA) is a well-characterized anti-HCV reagent. Recently it was reported that the genotype 2a JFH-1 strain was more resistant than genotype 1 HCV strains to CsA in a cell culture system. However, the JFH-1 responsible region for the resistance to CsA remains unclear. It was also demonstrated that in genotype 1b HCVs, NS5B interacts with cyclophilin (CyP). To clarify whether or not NS5B of JFH-1 is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19779801
DOI: 10.1007/s00705-009-0502-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HCV genotype 1b chimeric replicon with NS5B of JFH-1 exhibited resistance to cyclosporine A.PMID 19779801Read ↗

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