Article
Selection and characterization of drug-resistant HCV replicons in vitro with a flow cytometry-based assay.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2009
Robotham Jason M, Nelson Heather B, Tang Hengli
Abstract excerpt
Because HCV RNA-dependent RNA polymerase is error-prone and the viral RNA has a high turnover rate, the genetic diversity of HCV is very high both in vitro and in vivo. The mutation rate in long-term replicon cultures approaches 3.0 x 10(-3) base substitutions/site/year in this in vitro replicati...
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