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Article

Mutations in the hepatitis C virus polymerase that increase RNA binding can confer resistance to cyclosporine A.

Hepatology (Baltimore, Md.) - 1 Jul 2009

Liu Zhe, Robida John M, Chinnaswamy Sreedhar, Yi Guanghui, Robotham Jason M, Nelson Heather B, Irsigler Andre, Kao C Cheng, Tang Hengli

Abstract excerpt

UNLABELLED: Hepatitis C virus (HCV) infection leads to acute and chronic liver diseases, and new classes of anti-HCV therapeutics are needed. Cyclosporine A (CsA) inhibits HCV replication and CsA derivatives that lack the immunosuppressive function are currently in clinical trials as candidate an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19489073
DOI: 10.1002/hep.22987
PMCID: PMC2727352

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19489073-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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