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Article

Cyclosporine inhibits a direct interaction between cyclophilins and hepatitis C NS5A.

PloS one - 23 Mar 2010

Fernandes Fiona, Ansari Israr-ul H, Striker Rob

Abstract excerpt

BACKGROUND: Hepatitis C Virus (HCV) infection is a leading indication for liver transplantation. HCV infection reoccurs almost universally post transplant, decreasing both graft longevity and patient survival. The immunosuppressant, cyclosporine A (CsA) has potent anti-HCV activity towards both HCV replicons and the genotype 2a cell culture infectious virus. Previously, we isolated mutations in the 1bN replicon...

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Identifiers

PMID: 20352119
DOI: 10.1371/journal.pone.0009815
PMCID: PMC2843741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cyclosporine inhibits a direct interaction between cyclophilins and hepatitis C NS5A.PMID 20352119Read ↗

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HCV genotype 1b chimeric replicon with NS5B of JFH-1 exhibited resistance to cyclosporine A.Semantic proximity Read ↗

A major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approach.Semantic proximity Read ↗

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Characterization of Hepatitis C Virus Subgenomic Replicon Resistance to Cyclosporine In VitroSemantic proximity Read ↗

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