Article
A major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approach.
PLoS pathogens - 23 Sept 2010
Yang Feng, Robotham Jason M, Grise Henry, Frausto Stephen, Madan Vanesa, Zayas Margarita, Bartenschlager Ralf, Robinson Margaret, Greenstein Andrew E, Nag Anita, Logan Timothy M, Bienkiewicz Ewa, Tang Hengli
Abstract excerpt
Since the advent of genome-wide small interfering RNA screening, large numbers of cellular cofactors important for viral infection have been discovered at a rapid pace, but the viral targets and the mechanism of action for many of these cofactors remain undefined. One such cofactor is cyclophilin A (CyPA), upon which hepatitis C virus (HCV) replication critically depends. Here we report a new genetic selection...
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