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Article

Characterization of Hepatitis C Virus Subgenomic Replicon Resistance to Cyclosporine In Vitro

22 Mar 2007

Abstract excerpt

Treatment of hepatitis C virus (HCV) infection has been met with less than satisfactory results due primarily to its resistance to and significant side effects from alpha interferon (IFN-alpha). New classes of safe and broadly acting treatments are urgently needed. Cyclosporine (CsA), an immunosuppressive and anti-inflammatory drug for organ transplant patients, has recently been shown to be highly effective in...

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PMID: 17376913
DOI: 10.1128/jvi.02524-06

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