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Article

A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages.

BMC microbiology - 22 Apr 2014

Pegoraro Gianluca, Eaton Brett P, Ulrich Ricky L, Lane Douglas J, Ojeda Jenifer F, Bavari Sina, DeShazer David, Panchal Rekha G

Abstract excerpt

BACKGROUND: Burkholderia pseudomallei (Bp), a Gram-negative, motile, facultative intracellular bacterium is the causative agent of melioidosis in humans and animals. The Bp genome encodes a repertoire of virulence factors, including the cluster 3 type III secretion system (T3SS-3), the cluster 1 type VI secretion system (T6SS-1), and the intracellular motility protein BimA, that enable the pathogen to invade both...

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Identifiers

PMID: 24750902
DOI: 10.1186/1471-2180-14-98
PMCID: PMC4077104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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