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Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion

9 Mar 2020

Abstract excerpt

Innate immunity responds to pathogens by producing alarm signals and activating pathways that make host cells inhospitable for pathogen replication. The intracellular bacterium Burkholderia thailandensis invades the cytosol, hijacks host actin, and induces cell fusion to spread to adjacent cells, forming multinucleated giant cells (MNGCs) which promote bacterial replication. We show that type I interferon (IFN)...

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PMID: 32150572
DOI: 10.1371/journal.ppat.1008364

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