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Burkholderia pseudomallei BimC Is Required for Actin-Based Motility, Intracellular Survival, and Virulence

22 Mar 2019

Abstract excerpt

The intracellular pathogen Burkholderia pseudomallei, the etiological agent of melioidosis in humans and various animals, is capable of survival and movement within the cytoplasm of host cells by a process known as actin-based motility. The bacterial factor BimA is required for actin-based motility through its direct interaction with actin and by mediating actin polymerization at a single pole of the bacterium to...

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PMID: 30968000
DOI: 10.3389/fcimb.2019.00063

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