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Article

proBDNF negatively regulates neuronal remodeling, synaptic transmission, and synaptic plasticity in hippocampus.

Cell reports - 8 May 2014

Yang Jianmin, Harte-Hargrove Lauren C, Siao Chia-Jen, Marinic Tina, Clarke Roshelle, Ma Qian, Jing Deqiang, Lafrancois John J, Bath Kevin G, Mark Willie, Ballon Douglas, Lee Francis S, Scharfman Helen E, Hempstead Barbara L

Abstract excerpt

Experience-dependent plasticity shapes postnatal development of neural circuits, but the mechanisms that refine dendritic arbors, remodel spines, and impair synaptic activity are poorly understood. Mature brain-derived neurotrophic factor (BDNF) modulates neuronal morphology and synaptic plasticity, including long-term potentiation (LTP) via TrkB activation. BDNF is initially translated as proBDNF, which binds...

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Source

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Identifiers

PMID: 24746813
DOI: 10.1016/j.celrep.2014.03.040
PMCID: PMC4118923

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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