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Article

Inhibiting proBDNF to mature BDNF conversion leads to ASD-like phenotypes in vivo.

Molecular psychiatry - 1 Nov 2024

Yang Feng, You He, Mizui Toshiyuki, Ishikawa Yasuyuki, Takao Keizo, Miyakawa Tsuyoshi, Li Xiaofei, Bai Ting, Xia Kun, Zhang Lingling, Pang Dizhou, Xu Yiran, Zhu Changlian, Kojima Masami, Lu Bai

Abstract excerpt

Autism Spectrum Disorders (ASD) comprise a range of early age-onset neurodevelopment disorders with genetic heterogeneity. Most ASD related genes are involved in synaptic function, which is regulated by mature brain-derived neurotrophic factor (mBDNF) and its precursor proBDNF in a diametrically opposite manner: proBDNF inhibits while mBDNF potentiates synapses. Here we generated a knock-in mouse line...

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Source

Identifiers

PMID: 38762692
DOI: 10.1038/s41380-024-02595-5

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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