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Article

Reduction in BDNF from Inefficient Precursor Conversion Influences Nest Building and Promotes Depressive-Like Behavior in Mice.

International journal of molecular sciences - 1 Jun 2020

Kojima Masami, Otabi Hikari, Kumanogoh Haruko, Toyoda Atsushi, Ikawa Masahito, Okabe Masaru, Mizui Toshiyuki

Abstract excerpt

We generated a knock-in mouse line in which the gene encoding brain-derived neurotrophic factor (Bdnf) was replaced with a sequence for proBDNF containing human single nucleotide polymorphisms encoding arginines proximal to the cleavage site (R125M and R127L). The ratio of the mature form of BDNF (mBDNF) to precursor BDNF (proBDNF) in hippocampal tissue lysates was decreased in a manner dependent on the number of...

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Identifiers

PMID: 32492978
DOI: 10.3390/ijms21113984
PMCID: PMC7312902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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