Article

Inhibiting proBDNF to mature BDNF conversion leads to autism-like phenotypes <i>in vivo</i>

2020-06-12

Abstract excerpt

Autism spectrum disorders (ASD) comprise a range of early age-onset neurodevelopment disorders with genetic heterogeneity. Most ASD related genes are involved in synaptic function, which is oppositely regulated by brain-derived neurotrophic factor (BDNF): the precursor proBDNF inhibits while mature BDNF (mBDNF) potentiates synapses. Here we generated a knock-in mouse line (BDNF met/leu ) in which the conversion o...

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Literature Corpus work: 254cc1b0-57aa-5070-8eae-0ff2956645d5
DOI: 10.1101/2020.06.12.149104

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