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Article

Rapid HIV disease progression following superinfection in an HLA-B27:05/B57:01-positive transmission recipient.

Retrovirology - 16 Jan 2018

Brener Jacqui, Gall Astrid, Hurst Jacob, Batorsky Rebecca, Lavandier Nora, Chen Fabian, Edwards Anne, Bolton Chrissy, Dsouza Reena, Allen Todd, Pybus Oliver G, Kellam Paul, Matthews Philippa C, Goulder Philip J R

Abstract excerpt

BACKGROUND: The factors determining differential HIV disease outcome among individuals expressing protective HLA alleles such as HLA-B*27:05 and HLA-B*57:01 remain unknown. We here analyse two HIV-infected subjects expressing both HLA-B*27:05 and HLA-B*57:01. One subject maintained low-to-undetectable viral loads for more than a decade of follow up. The other progressed to AIDS in < 3 years. RESULTS: The rapid...

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Share to CD4 Lymphocyte Count
Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gag Gene Products, Human Immunodeficiency Virus

Share to HIV Core Protein p24

Share to HLA-B Antigens

Share to Sequence Analysis, RNA

Share to Superinfection

Share to T-Lymphocytes, Cytotoxic

Source

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Identifiers

PMID: 29338738
DOI: 10.1186/s12977-018-0390-9
PMCID: PMC5771019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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