Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Early HLA-B*57-restricted CD8+ T lymphocyte responses predict HIV-1 disease progression.

Journal of virology - 1 Oct 2012

Brennan Catherine A, Ibarrondo F Javier, Sugar Catherine A, Hausner Mary Ann, Shih Roger, Ng Hwee L, Detels Roger, Margolick Joseph B, Rinaldo Charles R, Phair John, Jacobson Lisa P, Yang Otto O, Jamieson Beth D

Abstract excerpt

Although HLA-B*57 (B57) is associated with slow progression to disease following HIV-1 infection, B57 heterozygotes display a wide spectrum of outcomes, including rapid progression, viremic slow progression, and elite control. Efforts to identify differences between B57-positive (B57(+)) slow progressors and B57(+) rapid progressors have largely focused on cytotoxic T lymphocyte (CTL) phenotypes and specificities...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acquired Immunodeficiency Syndrome
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes

Share to gag Gene Products, Human Immunodeficiency Virus

Share to Gene Expression Regulation, Viral

Share to HLA-B Antigens

Share to Models, Statistical

Share to T-Lymphocytes, Cytotoxic

Source

Open in PubMed Open full text

Identifiers

PMID: 22811521
DOI: 10.1128/JVI.00102-12
PMCID: PMC3457253

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Early HLA-B*57-restricted CD8+ T lymphocyte responses predict HIV-1 disease progression.PMID 22811521Read ↗

Characterization of HLA-B57-restricted human immunodeficiency virus type 1 Gag- and RT-specific cytotoxic T lymphocyte responses.Semantic proximity Read ↗

Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection.Semantic proximity Read ↗

Novel, Cross-Restricted, Conserved, and Immunodominant Cytotoxic T Lymphocyte Epitopes in Slow Progressors in HIV Type 1 InfectionSemantic proximity Read ↗

Rapid HIV disease progression following superinfection in an HLA-B*27:05/B*57:01-positive transmission recipient.Semantic proximity Read ↗

Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutations.Semantic proximity Read ↗

Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection.Semantic proximity Read ↗

Virological and immunological factors associated with HIV-1 differential disease progression in HLA-B 58:01-positive individuals.Semantic proximity Read ↗

Functional avidity and IL-2/perforin production is linked to the emergence of mutations within HLA-B*5701-restricted epitopes and HIV-1 disease progression.Semantic proximity Read ↗

Protective HLA Alleles Recruit Biased and Largely Similar Antigen-Specific T Cell Repertoires across Different Outcomes in HIV Infection.Semantic proximity Read ↗

HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors.Semantic proximity Read ↗

Recognition of a defined region within p24 gag by CD8+ T cells during primary human immunodeficiency virus type 1 infection in individuals expressing protective HLA class I alleles.Semantic proximity Read ↗

Immunological Control of HIV-1 Disease Progression by Rare Protective HLA Allele.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.