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Article

Cellular heterogeneity profiling by hyaluronan probes reveals an invasive but slow-growing breast tumor subset.

Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 2014

Veiseh Mandana, Kwon Daniel H, Borowsky Alexander D, Tolg Cornelia, Leong Hon S, Lewis John D, Turley Eva A, Bissell Mina J

Abstract excerpt

Tumor heterogeneity confounds cancer diagnosis and the outcome of therapy, necessitating analysis of tumor cell subsets within the tumor mass. Elevated expression of hyaluronan (HA) and HA receptors, receptor for HA-mediated motility (RHAMM)/HA-mediated motility receptor and cluster designation 44 (CD44), in breast tumors correlates with poor outcome. We hypothesized that a probe for detecting HA-HA receptor...

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Identifiers

PMID: 24733940
DOI: 10.1073/pnas.1402383111
PMCID: PMC4035999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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