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Article

Functional heterogeneity within the CD44 high human breast cancer stem cell-like compartment reveals a gene signature predictive of distant metastasis.

Molecular medicine (Cambridge, Mass.) - 25 Sept 2012

Leth-Larsen Rikke, Terp Mikkel G, Christensen Anne G, Elias Daniel, Kühlwein Thorsten, Jensen Ole N, Petersen Ole W, Ditzel Henrik J

Abstract excerpt

The CD44(hi) compartment in human breast cancer is enriched in tumor-initiating cells; however, the functional heterogeneity within this subpopulation remains poorly defined. We used a triple-negative breast cancer cell line with a known bilineage phenotype to isolate and clone CD44(hi) single cells that exhibited mesenchymal/basal B and luminal/basal A features, respectively. Herein, we demonstrate in this and...

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Share to CD24 Antigen
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22692575
DOI: 10.2119/molmed.2012.00091
PMCID: PMC3474436

Genes

LSR
MUC1
RAB25

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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