Article
Post-translational decrease in respiratory chain proteins in the Polg mutator mouse brain.
PloS one - 1 Jan 2014
Hauser David N, Dillman Allissa A, Ding Jinhui, Li Yan, Cookson Mark R
Abstract excerpt
Mitochondrial DNA damage is thought to be a causal contributor to aging as mice with inactivating mutations in polymerase gamma (Polg) develop a progeroid phenotype. To further understand the molecular mechanisms underlying this phenotype, we used iTRAQ and RNA-Seq to determine differences in protein and mRNA abundance respectively in the brains of one year old Polg mutator mice compared to control animals. We...
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