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Article

Transcriptomic and epigenetic characterization of paraventricular thalamic nucleus neurons in Polg1 mutant mice.

Neuroscience research - 1 Aug 2026

Bagge Emilie Kristine, Kubota-Sakashita Mie, Fujimori-Tonou Noriko, Kasahara Takaoki, Kato Tadafumi

Abstract excerpt

How damaged mitochondrial DNA (mtDNA) affects gene expression in mtDNA-related diseases is not well understood. Here, we investigated the changes in the transcriptome and chromatin modifications associated with the accumulation of mtDNA mutations in a proof-reading-deficient mitochondrial DNA polymerase transgenic mouse (Polg1 mutant mice), which accumulate mtDNA mutations preferentially in the paraventricular...

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Identifiers

PMID: 42398644
DOI: 10.1016/j.neures.2026.105089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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