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Article

The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions.

Nature communications - 27 Jun 2018

Nissanka Nadee, Bacman Sandra R, Plastini Melanie J, Moraes Carlos T

Abstract excerpt

Double-strand breaks in the mitochondrial DNA (mtDNA) result in the formation of linear fragments that are rapidly degraded. However, the identity of the nuclease(s) performing this function is not known. We found that the exonuclease function of the mtDNA polymerase gamma (POLG) is required for this rapid degradation of mtDNA fragments. POLG is recruited to linearized DNA fragments in an origin of...

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Share to DNA Breaks, Double-Stranded
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29950568
DOI: 10.1038/s41467-018-04895-1
PMCID: PMC6021392

Genes

POLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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