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Article

Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain.

Neurobiology of aging - 1 Nov 2015

Clark-Matott Joanne, Saleem Ayesha, Dai Ying, Shurubor Yevgeniya, Ma Xiaoxing, Safdar Adeel, Beal Myron Flint, Tarnopolsky Mark, Simon David K

Abstract excerpt

Mitochondrial DNA (mtDNA) mutator mice express a mutated form of mtDNA polymerase gamma that results an accelerated accumulation of somatic mtDNA mutations in association with a premature aging phenotype. An exploratory metabolomic analysis of cortical metabolites in sedentary and exercised mtDNA mutator mice and wild-type littermate controls at 9-10 months of age was performed. Pathway analysis revealed deficits...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26294258
DOI: 10.1016/j.neurobiolaging.2015.07.020
PMCID: PMC4609600

Genes

PARP1
POLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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