Article
A central role for GRB10 in regulation of islet function in man.
PLoS genetics - 1 Apr 2014
Prokopenko Inga, Poon Wenny, Mägi Reedik, Prasad B Rashmi, Salehi S Albert, Almgren Peter, Osmark Peter, Bouatia-Naji Nabila, Wierup Nils, Fall Tove, Stančáková Alena, Barker Adam, Lagou Vasiliki, Osmond Clive, Xie Weijia, Lahti Jari, Jackson Anne U, Cheng Yu-Ching, Liu Jie, O'Connell Jeffrey R, Blomstedt Paul A, Fadista Joao, Alkayyali Sami, Dayeh Tasnim, Ahlqvist Emma, Taneera Jalal, Lecoeur Cecile, Kumar Ashish, Hansson Ola, Hansson Karin, Voight Benjamin F, Kang Hyun Min, Levy-Marchal Claire, Vatin Vincent, Palotie Aarno, Syvänen Ann-Christine, Mari Andrea, Weedon Michael N, Loos Ruth J F, Ong Ken K, Nilsson Peter, Isomaa Bo, Tuomi Tiinamaija, Wareham Nicholas J, Stumvoll Michael, Widen Elisabeth, Lakka Timo A, Langenberg Claudia, Tönjes Anke, Rauramaa Rainer, Kuusisto Johanna, Frayling Timothy M, Froguel Philippe, Walker Mark, Eriksson Johan G, Ling Charlotte, Kovacs Peter, Ingelsson Erik, McCarthy Mark I, Shuldiner Alan R, Silver Kristi D, Laakso Markku, Groop Leif, Lyssenko Valeriya
Abstract excerpt
Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably reduced fasting glucose when inherited from the...
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