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Imprinted <i>Grb10</i> , encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor ( <i>Igf1r</i> ) and insulin receptor ( <i>Insr</i> ) genes

2024-01-24

Abstract excerpt

<h4>Background</h4> Optimal size at birth dictates perinatal survival and long-term risk of developing common disorders such as obesity, type 2 diabetes and cardiovascular disease. The imprinted Grb10 gene encodes a signalling adaptor protein capable of inhibiting receptor tyrosine kinases, including the insulin receptor (Insr) and insulin-like growth factor type 1 receptor (Igf1r). Grb10 restricts fetal growth...

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Literature Corpus work
e1b2dd8c-6cb7-531a-8cd6-7cfc4d503bf7
DOI
10.1101/2024.01.24.576998
Open publication

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Imprinted <i>Grb10</i> , encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor ( <i>Igf1r</i> ) and insulin receptor ( <i>Insr</i> ) genesDOI 10.1101/2024.01.24.576998
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