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Developmental Programming Mediated by Complementary Roles of Imprinted Grb10 in Mother and Pup

25 Feb 2014

Abstract excerpt

Developmental programming links growth in early life with health status in adulthood. Although environmental factors such as maternal diet can influence the growth and adult health status of offspring, the genetic influences on this process are poorly understood. Using the mouse as a model, we identify the imprinted gene Grb10 as a mediator of nutrient supply and demand in the postnatal period. The combined...

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PMID: 24586114
DOI: 10.1371/journal.pbio.1001799

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Developmental Programming Mediated by Complementary Roles of Imprinted Grb10 in Mother and PupPMID 24586114Read ↗

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Imprinted <i>Grb10</i> , encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor ( <i>Igf1r</i> ) and insulin receptor ( <i>Insr</i> ) genesSemantic proximity Read ↗

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