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Article

Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets.

PLoS genetics - 1 Nov 2014

Olsson Anders H, Volkov Petr, Bacos Karl, Dayeh Tasnim, Hall Elin, Nilsson Emma A, Ladenvall Claes, Rönn Tina, Ling Charlotte

Abstract excerpt

Genetic and epigenetic mechanisms may interact and together affect biological processes and disease development. However, most previous studies have investigated genetic and epigenetic mechanisms independently, and studies examining their interactions throughout the human genome are lacking. To identify genetic loci that interact with the epigenome, we performed the first genome-wide DNA methylation quantitative...

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Source

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Identifiers

PMID: 25375650
DOI: 10.1371/journal.pgen.1004735
PMCID: PMC4222689

Genes

ADCY5
CIT
GPX7
GRB10
GSTT1
INS
KCNJ11
PDX1
SNX19

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